GSK-3beta inhibitor 13 (compound 47) is an orally active and potent GSK-3beta inhibitor with blood-brain permeability. GSK-3beta inhibitor 13 inhibits GSK-3beta and GSK-3alpha with IC50s of 0.73 nM and 0.35 nM, respectively. GSK-3beta inhibitor 13 significantly decreases the phosphorylation of tau (IC50=58 nM), which leads the formation of the neurofibrillary tangles associated with Alzheimers disease[1].
Molecular Weight:
414.46
Purity:
99.74
CAS Number:
[2227316-74-5]
Formula:
C23H22N6O2
Target:
AAK1,GSK-3,Pim,PKC,Tau Protein
Application Notes:
Reference compound
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