MR22 is a potent pan-SIK (salt-inducible kinase) inhibitor. MR22 no longer exhibits activity on STE group kinases and displays excellent selectivity in a representative kinase panel. MR22-dependent SIK inhibition led to centrosome dissociation and subsequent cell-cycle arrest in ovarian cancer cells[1].
Molecular Weight:
359.37
Purity:
99.76
CAS Number:
[3027761-24-3]
Formula:
C18H19F2N5O
Target:
Salt-inducible Kinase (SIK)
Application Notes:
MCE Product type: Reference compound
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