AChE/BuChE/MAO-B-IN-2 (compound 4b) is a potent AChE/BuChE inhibitor and showed good blood brain barrier (BBB) permeability in vitro with an IC50 value of 5.3 µM, 12.4 µM, 1.90.08 µM, for AChE, BuChE, huMAO-B, respectively. AChE/BuChE/MAO-B-IN-2 (compound 4b) can inhibit excess AChE/BuChE in Alzheimers disease (AD) brain. AChE/BuChE/MAO-B-IN-2 (compound 4b) can be used in anti-Alzheimers research[1].
Molecular Weight:
327.35
Formula:
C19H18FNO3
Target:
Cholinesterase (ChE),Monoamine Oxidase
Application Notes:
Reference compound
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