MORF-627 is a selective, orally active inhibitor for integrin alphavbeta6 with an IC50 of 9.2 nM measuring by human serum ligand binding assay. MORF-627 inhibits alphavbeta6-mediated TGF-beta1 activation with an IC50 of 2.63 nM, inhibits SMAD2/3 phosphorylation with an IC50 of 8.3 nM. MORF-627 ameliorates the Bleomycin (HY-108345)-induced mouse lung fibrosis[1].
Molecular Weight:
537.67
CAS Number:
[2412688-16-3]
Formula:
C31H40FN3O4
Target:
Integrin,TGF-beta/Smad
Application Notes:
MCE Product type: Reference compound
* VAT and and shipping costs not included. Errors and price changes excepted