HDAC-IN-53 is an orally active, and selective HDAC1-3 inhibitor with IC50 values of 47 nM, 125 nM, and 450 nM, respectively. HDAC-IN-53 does not inhibit class II HDACs (HDAC4, 5, 6, 7, 9, IC50>10 µM). HDAC-IN-53 induces caspase-dependent apoptosis. HDAC-IN-53 significantly inhibits the growth of human tumor xenografts in nude mice and murine tumor growth in immune-competent mice bearing MC38 colon cancer[1].
Molecular Weight:
461.90
Purity:
95.73
CAS Number:
[2921948-27-6]
Formula:
C23H20ClN7O2
Target:
Apoptosis,HDAC
Application Notes:
MCE Product type: Reference compound
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