CLK1-IN-3 (compound 10ad) is a potent and selective Clk1 inhibitor, with an IC50 of 5 nM and over 300-fold selectivity for Dyrk1A. CLK1-IN-3 also shows a relatively potent inhibition against Clk2 and Clk4, with IC50 values of 42 and 108 nM, respectively. CLK1-IN-3 potently induces autophagy in vitro. CLK1-IN-3 can be used for acute liver injury (ALI) research[1].
Molecular Weight:
430.48
Purity:
98.54
CAS Number:
[2922550-28-3]
Formula:
C24H23FN6O
Target:
Autophagy,CDK,DYRK
Application Notes:
MCE Product type: Reference compound
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