Berubicin (RTA 744 free base) is a Doxorubicin (HY-15142A) analog that can cross the blood-brain barrier. Berubicin inhibits P-gp and MRP1-mediated efflux and suppresses glioblastoma multiforme (GBM). Berubicin exerts toxic effects on leukemia cells by activating nuclear factor kappaB (NF-kappaB) and induces apoptosis in neuroblastoma cells. Berubicin can be used in the study of tumors related to the nervous system[1][2][3][4][5].
Molecular Weight:
633.64
Purity:
87.76
CAS Number:
[677017-23-1]
Formula:
C34H35NO11
Target:
Apoptosis,Caspase,NF-kappaB
Application Notes:
MCE Product type: Reference compound
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