SIRT5 inhibitor 7 (compound 58) is a substrate-competitive and selective SIRT5 inhibitor with anti-inflammatory activity. SIRT5 inhibitor 7 has renal protective effects and regulates protein succinylation and the release of pro-inflammatory cytokines. SIRT5 inhibitor 7 has in vivo activity in AKI mouse models of lipopolysaccharide (LPS) and cecal ligation/perforation (CLP)-induced sepsis-related acute kidney injury[1].
Molecular Weight:
582.12
CAS Number:
[2951090-00-7]
Formula:
C28H32ClN7O3S
Target:
Sirtuin
Application Notes:
MCE Product type: Reference compound
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