NDNA4 (compound 17) is a selective inhibitor of Hsp90alpha (IC50: 0.34 µM). NDNA4 is a permanently charged analog with low membrane permeability and low cytotoxicity against Ovcar-8 and MCF-10A ((IC50 >100 µM)). NDNA4 prevents disruption of hERG channel maturation without generating a heat shock response or causing degradation of Hsp90alpha-dependent client proteins[1].
Molecular Weight:
604.68
Formula:
C31H35F3N2O5S
Target:
HSP,Potassium Channel
Application Notes:
MCE Product type: Reference compound
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