BWA-522 is an orally available small molecule protein-targeting chimera (PROTACs) with significant degradation effect on AR-FL and AR-V7. BWA-522 antagonizes the N-terminal domain (AR-NTD) of the androgen receptor (Androgen Receptor) and induces apoptosis in PC cells. BWA-522 inhibits tumor growth in LNCaP xenograft model studies (60 mg/kg, po, TGI=76%). The efficiencies of BWA-522 in degrading AR-V7 and AR-FL were 77.3% (1 µM) and 72.0% (5 µM) in VCaP and LNCaP cells, respectively[1].
Molecular Weight:
771.34
Purity:
99.93
CAS Number:
[3042820-12-9]
Formula:
C43H51ClN4O7
Target:
Androgen Receptor,Apoptosis
Application Notes:
MCE Product type: Reference compound
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