BWA-522 is an orally active PROTAC degrader targeting full-length androgen receptor (AR-FL) and androgen receptor splice variant 7 (AR-V7). BWA-522 antagonizes the N-terminal domain (AR-NTD) of the androgen receptor, suppresses AR downstream signaling proteins and induces cancer cells apoptosis. BWA-522 inhibits tumor growth in LNCaP xenograft mouse model. BWA-522 can be used for the research of prostate cancer[1].
Molecular Weight:
771.34
Purity:
98.04
CAS Number:
[3042820-12-9]
Formula:
C43H51ClN4O7
Target:
Androgen Receptor,Apoptosis,PROTACs
Application Notes:
MCE Product type: Reference compound
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