SYHA1815 is an orally active RET inhibitor (IC50=0.9 nmol/L) with antitumor activity. SYHA1815 is more selective for RET than KDR (IC50=15.9 nmol/L). SYHA1815 arrests the G1 cell cycle and inhibits RET-driven cell proliferation by downregulating c-Myc[1].
Molecular Weight:
547.97
CAS Number:
[2760195-67-1]
Formula:
C27H26ClF4N5O
Target:
c-Myc,RET,VEGFR
Application Notes:
Reference compound
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