JT002 is an orally active and selective NLRP3 inflammasome assembly inhibitor. JT002 reduces NLRP3-dependent proinflammatory cytokine (such as IL-1beta, IL-1alpha, IL-18) production and pyroptosis. JT002 blocks NLRP3 inflammasome complex formation. JT002 reduces airway hyperresponsiveness and airway neutrophilia in mice. JT002 can be used for the study of a variety of inflammatory diseases, such as Muckle-Wells syndrome (MWS)[1].
Molecular Weight:
432.49
Purity:
99.54
CAS Number:
[2238820-43-2]
Formula:
C20H24N4O5S
Target:
NOD-like Receptor (NLR),Pyroptosis
Application Notes:
Reference compound
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