Nrf2-IN-3, CAS [[6325-13-9]]

Product Overview

• Article Name: Nrf2-IN-3, CAS [[6325-13-9]]
• Biozol Catalog Number: MCE-HY-149508
• Supplier Catalog Number: HY-149508
• Alternative Catalog Number: MCE-HY-149508-100MG,MCE-HY-149508-5MG,MCE-HY-149508-250MG,MCE-HY-149508-50MG,MCE-HY-149508-10MG,MCE-HY-149508-1G,MCE-HY-149508-500MG,MCE-HY-149508-10MMX1ML,MCE-HY-149508-25MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien

Product Description

Nrf2-IN-3 (Compound R16) is a small-molecule NRF2 inhibitor and increases reactive oxygen species (ROS) production. Nrf2-IN-3 selectively binds KEAP1 mutants and restores their NRF2-inhibitory function by repairing the disrupted KEAP1/NRF2 interactions, leading to proteasome-dependent NRF2 degradation in cells. Nrf2-IN-3 sensitizes KEAP1-mutated tumor cells to Cisplatin (HY-17394), Gefitinib (HY-50895), and KEAP1 G333C-mutated xenograft to Cisplatin [1].

Product Properties

• Molecular Weight: 442.53
• Purity: 99.19
• CAS Number: [6325-13-9]
• Formula: C22H26N4O4S
• Target: Keap1-Nrf2,Reactive Oxygen Species (ROS)

Application Notes

• Application Notes: Reference compound