EGFR/BRAFV600E-IN-2 (compound 3g) is a potential multi-target inhibitor of EGFR, BRAFV600E, and EGFRT790M, and an inducer of apoptosis. EGFR/BRAFV600E-IN-2 can activate caspase-3, 8, and Bax, and downregulate the anti-apoptotic protein Bcl2, inducing apoptosis. EGFR/BRAF V600E-IN-2 also has antioxidant activity and DPPH free radical scavenging potency[1].
Molecular Weight:
406.44
Formula:
C25H18N4O2
Target:
Apoptosis,Bcl-2 Family,Caspase,EGFR,Raf
Application Notes:
Reference compound
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