Anticancer agent 157 (compound 15) is a NO inhibitor (IC50=0.62 µg/mL) with anti-inflammatory and anticancer activities. Anticancer agent 157 can bind to iNOS (inducible NO synthase) and caspase 8, causing nuclear fragmentation and chromatin condensation, inducing apoptosis. Anticancer agent 157 inhibits HT29 colon cancer cells (IC50=2.45 µg/mL), Hep-G2 liver cancer cells (IC50=3.25 µg/mL), and B16-F10 murine melanoma cells (IC50=3.84 µg/mL)[1].
Molecular Weight:
220.31
Formula:
C14H20O2
Target:
Apoptosis,Caspase,NO Synthase
Application Notes:
Reference compound
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