GSK-3beta inhibitor 15 (Compound 54) is a GSK-3beta inhibitor (IC50: 3.4 nM). GSK-3beta inhibitor 15 inhibits Abeta1-42-induced GSK-3beta and tau protein phosphorylation. GSK-3beta inhibitor 15 inhibits LPS-induced iNOS expression. GSK-3beta inhibitor 15 has neuroprotective effects on Abeta1-42-induced neurotoxicity. GSK-3beta inhibitor 15 can be used for research of Alzheimers disease (AD)[1].
Molecular Weight:
352.41
Formula:
C17H16N6OS
Target:
Apoptosis,GSK-3,Tau Protein
Application Notes:
Reference compound
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