EGFR/HER2/DHFR-IN-3 (compound 4c) is a potent dual inhibitor of EGFR/HER2, with IC50s of 0.138 and 0.092 µM, respectively. EGFR/HER2/DHFR-IN-3 also inhibits DHFR, with an IC50 of 0.193 M. EGFR/HER2/DHFR-IN-3 causes arrest at the S phase of the cell cycle and induces apoptosis in MCF7 breast cancer cells[1].
Molecular Weight:
373.40
Formula:
C22H19N3O3
Target:
Apoptosis,Dihydrofolate reductase (DHFR) ,EGFR
Application Notes:
MCE Product type: Reference compound
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