BMS-332 is a dual DGKalpha/zeta lipid kinase inhibitor, with IC50s of 5 and 1 nM against DGKalpha and DGKzeta, respectively. BMS-332 enhances the antigen-specific T cell response. BMS-332 reduces the viral load in the liver and spleen when combined with anti-PD-1 in chronic infection models. BMS-332 can be used for the study of T cell immune checkpoint strategy[1].
Molecular Weight:
499.55
Purity:
99.05
CAS Number:
[2407892-15-1]
Formula:
C29H27F2N5O
Target:
DGK
Application Notes:
MCE Product type: Reference compound
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