TRK-IN-23 (compound 24b) is a potent and orally active TRK inhibitor with IC50 values of 0.5 nM, 9 nM, 14 nM, 4.4 nM, and 4.8 nM against TRKA, TRKC, TRKAG595R, TRKAF589L, and TRKAG667C, respectively. TRK-IN-23 indues apoptosis of Ba/F3-TRKAG595Rand Ba/F3-TRKAG667C cells[1].
Molecular Weight:
364.37
CAS Number:
[2924344-29-4]
Formula:
C20H17FN4O2
Target:
Apoptosis,Trk Receptor
Application Notes:
MCE Product type: Reference compound
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