Icovamenib, CAS [[2448172-22-1]]

Product Overview

• Article Name: Icovamenib, CAS [[2448172-22-1]]
• Biozol Catalog Number: MCE-HY-150105
• Supplier Catalog Number: HY-150105
• Alternative Catalog Number: MCE-HY-150105-10MG,MCE-HY-150105-5MG,MCE-HY-150105-10MMX1ML,MCE-HY-150105-100MG,MCE-HY-150105-50MG,MCE-HY-150105-25MG
• Manufacturer: MedchemExpress
• Category: Biochemikalien
• Alternative Names: BMF-219, Menin-MLL inhibitor 21

Product Description

Icovamenib (BMF-219) is a selective, orally active, irreversible Menin inhibitor. Icovamenib forms a stable and irreversible covalent bond with Menin. Icovamenib promotes selective and controlled proliferation of beta cells and improvement of beta cell function in ex vivo human islet cultures. Icovamenib enhances glycemic control in animal diabetic models. Icovamenib induces a dose-dependent enhancement in insulin secretion potentiated by the GLP-1 RA. Icovamenib can be used for the study of multiple hematologic malignancies, solid tumors, and diabetes mellitus, such as diffuse large B-cell lymphoma (DLBCL), multiple myeloma (MM) and chronic lymphocytic leukemia and type 2 diabetes[1][2][3][4][5].

Product Properties

• Molecular Weight: 566.65
• Purity: 98.96
• CAS Number: [2448172-22-1]
• Formula: C31H34N8O3
• Target: Epigenetic Reader Domain

Application Notes

• Application Notes: MCE Product type: Reference compound1