RMC-4745 is a selective dual-site inhibitor of mTORC1, with a selectivity of 35 times for mTORC1 and mTORC2. RMC-4745 inhibits the proliferation of MCF-7 cells and upregulates Caspase-3/7 activity to induce cell apoptosis. RMC-4745 does not cause the upregulation of HER3 due to the inhibition of mTORC2. RMC-4745 can be used for the study of breast cancer[1].
Molecular Weight:
1824.20
CAS Number:
[2250059-80-2]
Formula:
C94H142N12O24
Target:
Apoptosis,Caspase,mTOR
Application Notes:
MCE Product type: Reference compound
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