HKSOX-1 and its derivatives (HKSOX-1r and HKSOX-1m) are novel fluorescent probes designed for highly sensitive and selective detection of the superoxide anion radical (O2-) in cellular environments. These probes utilize an aryl trifluoromethanesulfonate group that undergoes O2--mediated cleavage, releasing a free phenol and emitting fluorescence. They demonstrate excellent specificity and sensitivity across various pH ranges, withstand interference from strong oxidants and reductants typical in cellular contexts. HKSOX-1r, optimized for cellular retention, has been effectively employed in diverse assays including confocal imaging, flow cytometry, and zebrafish embryo studies, highlighting its utility in investigating O2- roles in inflammation, mitochondrial stress, and other physiological processes[1].
Molecular Weight:
712.40
CAS Number:
[1786411-17-3]
Formula:
C23H6F10O11S2
Target:
Fluorescent Dye
Application Notes:
MCE Product type: Dye Reagents
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