And1-IN-1 is a potent And1 inhibitor with an IC50 of 2.08 µM. And1-IN-1 binds to the N-terminus of And-1 and induces a conformational change in And-1, which promotes the interaction of And-1 with E3 ligase CUL4B for ubiquitin-mediated degradation. And1-IN-1 suppresses the growth of a broad range of cancers and resensitizes platinum-resistant ovarian cancer cells to platinum agents. And1-IN-1 can be used for the studies of ovarian cancer and breast cancer[1].
Molecular Weight:
304.96
Purity:
98.01
CAS Number:
[2451028-69-4]
Formula:
C15H11BCl2O2
Target:
DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference compound
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