F5446 (Compound 1) is a selective small molecule inhibitor of SUV39H1 methyltransferase. F5446 decreases H3K9me3 deposition at the FAS promoter, increases Fas expression and increases colorectal carcinoma cell sensitivity to FasL-induced apoptosis in vitro. F5446 suppresses human colon tumor xenograft growth in vivo[1][2][3].
Molecular Weight:
552.94
Purity:
99.38
CAS Number:
[2304465-89-0]
Formula:
C26H17ClN2O8S
Target:
Apoptosis,Histone Methyltransferase
Application Notes:
MCE Product type: Reference compound1
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