GSK3735967 is an selective, reversible, non-nucleoside inhibitor of DNMT1 with an IC50 value of 40 nM. GSK3735967 contains a planar dicyanopyridine core that can specifically embed DNMT1 bound hemimethylated CpG dinucleotides. GSK3735967 has three binding sites, one of which can bind to histone H4K20me3[1][2].
Molecular Weight:
477.62
Purity:
99.34
CAS Number:
[2170136-86-2]
Formula:
C25H31N7OS
Target:
DNA Methyltransferase
Application Notes:
MCE Product type: Reference compound1
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