SD-91 (STAT3 degrader-2), a product of the hydrolysis of SD-36 (HY-129602), is a selective PROTAC-based STAT3 degrader with a Ki of 5.5 nM. SD-91 displays >300-fold selectivity over other STAT family protein members. SD-91 potently induces degradation of STAT3 protein in cells. SD-91 has anticancer effects, such as myeloid leukemia, lymphoma (Pink: ligand for target protein (HY-150895), Black: linker, Blue: E3 ligase ligand, E3 ligase ligand+linker: HY-176506)[1][2].
Molecular Weight:
1136.15
CAS Number:
[2497583-03-4]
Formula:
C59H62N9O13P
Target:
PROTACs,STAT
Application Notes:
MCE Product type: Reference compound1
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