PolQi2 is a PolT inhibitor that targets and inhibits alt-EJ (alternative end-joining) repair by inhibiting the helicase domain at the N-terminus of PolT. PolQi2 enhances the precision and integration efficiency of gene editing at different loci and in various cell lines. Furthermore, the combined use of PolQi2 with DNA-PK inhibitors reduces the off-target effects of Cas9. PolQi2 can be used in gene editing research[1][2].
Molecular Weight:
453.90
Purity:
99.65
CAS Number:
[2565638-16-4]
Formula:
C21H16ClN5O3S
Target:
DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference compound1
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