Farabursen (RGLS8429, RG1015) is a blood-brain barrier-permeable miR-17 inhibitor. Farabursen derepresses Pkd1 and Pkd2, the target genes of miR-17, increases the levels of PC1 and PC2, and reduces cyst growth. Farabursen decreases renal cyst growth, kidney weight-to-body weight ratio, cyst index, proliferation index, and blood urea nitrogen levels in mouse models. Farabursen is applicable to research related to autosomal dominant polycystic kidney disease[1][2].
Molecular Weight:
3066.36
Purity:
97.59
CAS Number:
[2953012-32-1]
Target:
MicroRNA
Application Notes:
MCE Product type: Oligonucleotides
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