MS8511 is a selective G9a/GLP covalent irreversible inhibitor by targeting a cysteine residue at the substrate binding site, with IC50 values of 100 nM (G9a) and 140 nM (GLP), and Kd values of 44 nM (G9a) and 46 nM (GLP). MS8511 reduces the cellular H3K9me2 level and enhances antiproliferation activity. MS8511 can be used for the research of several types of cancers including brain, breast, ovarian, lung, bladder, melanoma, colorectal cancer, and other disease such as Alzheimers disease (AD), sickle cell disease, Prader-Willi syndrome (PWS)[1].
Molecular Weight:
495.66
Purity:
99.82
CAS Number:
[2866408-21-9]
Formula:
C28H41N5O3
Target:
Histone Methyltransferase
Application Notes:
MCE Product type: Reference compound
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