ARN1468 (compound 5) is an orally active and potent SerpinA3n inhibitor. ARN1468 can inhibit serpins activity would set the protease free to further reduce prion accumulation. ARN1468 shows anti-prion effect in ScGT1 RML, ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, with EC50 values of 8.64, 19.3, 11.2, and 6.27 µM[1].
Molecular Weight:
354.33
Purity:
98.96
CAS Number:
[1381459-14-8]
Formula:
C16H17F3N4O2
Target:
Prion Protein
Application Notes:
MCE Product type: Reference compound1
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