(R)-STU104 is a potent and orally active TAK1-MKK3 interaction inhibitor with IC50s of 0.58 µM and 4.0 µM for TNF-alpha and MKK3 phosphorylation. (R)-STU104 suppresses the TAK1/MKK3/p38/MnK1/MK2/elF4E signal pathways through binding with MKK3 and disrupting the TAK1 phosphorylating MKK3. (R)-STU104 can be used for researching ulcerative colitis[1].
Molecular Weight:
298.33
Purity:
99.91
CAS Number:
[2767124-77-4]
Formula:
C18H18O4
Target:
p38 MAPK
Application Notes:
MCE Product type: Reference compound
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