(R)-STU104-d6 is a deuterium labeled (R)-STU104 (HY-150612). (R)-STU104 is a potent and orally active TAK1-MKK3 interaction inhibitor with IC50s of 0.58 µM and 4.0 µM for TNF-alpha and MKK3 phosphorylation. (R)-STU104 suppresses the TAK1/MKK3/p38/MnK1/MK2/elF4E signal pathways through binding with MKK3 and disrupting the TAK1 phosphorylating MKK3. (R)-STU104 can be used for researching ulcerative colitis[1].
Molecular Weight:
304.37
Purity:
99.90
CAS Number:
[3063042-81-6]
Formula:
C18H12D6O4
Target:
Isotope-Labeled Compounds,p38 MAPK
Application Notes:
MCE Product type: Isotope-Labeled Compounds
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