RLX-33 is a potent, selective and blood-brain barrier (BBB) penetrant relaxin family peptide 3 (RXFP3) antagonist, also blocks relaxin-3-induced ERK1/2 phosphorylation, with IC50 values of 2.36 µM for RXFP3, 7.82 and 13.86 µM for ERK1 and ERK2 phosphorylation, respectively. RLX-33 can block the stimulation of food intake induced by the RXFP3-selective agonist R3/I5 in rats. RLX-33 can be used for the research of metabolic syndrome[1].
Molecular Weight:
462.89
Purity:
99.79
CAS Number:
[2784577-71-3]
Formula:
C24H19ClN4O4
Target:
ERK
Application Notes:
MCE Product type: Reference compound
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