ODN 2216 sodium is a human-specific TLR9 (toll-like receptor 9) ligand or agonist. ODN 2216 sodium induces high amounts of IFN-alpha and IFN-beta. ODN 2216 sodium induces IFN-alpha by pDC (plasmacytoid DC) and IL-12 (p40) production by DC (dendritic cells). ODN 2216 sodium stimulates IFN-gamma production in peripheral blood mononuclear cells (PBMC), which is indirect and mediated by IFN-alpha/beta. ODN 2216 sodium can activate NK cells and promote IFN-gamma production of TCR-triggered CD4+ T cells[1][2][3][4][5].
Molecular Weight:
6432 (free acid)
Purity:
98.57
Target:
Toll-like Receptor (TLR)
Application Notes:
MCE Product type: Oligonucleotides
* VAT and and shipping costs not included. Errors and price changes excepted