ODN 2216 (sodium)

Product Overview

• Article Name: ODN 2216 (sodium)
• Biozol Catalog Number: MCE-HY-150741C
• Supplier Catalog Number: HY-150741C
• Alternative Catalog Number: MCE-HY-150741C-1MG,MCE-HY-150741C-10MG,MCE-HY-150741C-25MG,MCE-HY-150741C-50MG,MCE-HY-150741C-100MG,MCE-HY-150741C-5MG
• Manufacturer: MedchemExpress
• Category: Sonstiges

Product Description

ODN 2216 sodium is a type A CpG oligodeoxynucleotide vaccine adjuvant and a TLR9 agonist. ODN 2216 sodium interacts with TLR9 in the lysosomes of CD4+ T cells and activates feedback-dependent signaling pathways. ODN 2216 sodium induces the production of type I interferons, IL-6 and TGF-beta via the IRAK4/IRF7 axis, while increasing intracellular ATP levels. ODN 2216 sodium not only induces the differentiation of CD4+ T cells into anti-inflammatory Th3-like regulatory phenotypes to inhibit autologous proliferation, but also enhances the specific CD8+ T cell-mediated cytotoxicity against Mammaglobin-A in breast cancer cells. ODN 2216 sodium is widely used in studies related to breast cancer and systemic lupus erythematosus[1][2][3].

Product Properties

• Molecular Weight: 6432 (free acid)
• Purity: 98.57
• Target: Toll-like Receptor (TLR)

Application Notes

• Application Notes: MCE Product type: Oligonucleotides