PARP1-IN-12 is a potent PARP1 inhibitor with an IC50 of 2.99 nM. PARP1-IN-12 exhibits antiproliferative activity, can induce cell apoptosis and cause cycle arrest at G2/M phase. PARP1-IN-12 also can induce DNA double strand breaks (DSBs) in BRCA-deficient cells[1].
Molecular Weight:
741.93
Formula:
C43H56FN5O5
Target:
Apoptosis,PARP
Application Notes:
MCE Product type: Reference compound
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