BMS-37 is a PD-1/PD-L1 immune checkpoint inhibitor with an IC50 towards the PD-L1/PD-1 complex in the range of 18 to 200 nM. BMS-37 shows unspecific toxicity against modified Jurkat T cells with an EC50 between 3 and 6 µM. BMS-37 can be used for the study of the PD-L1-induced exhaustion of T-cells or as PD-L1 ligand to synthesize PROTAC molecules[1][2][3].
Molecular Weight:
448.55
Purity:
98.01
CAS Number:
[1675202-20-6]
Formula:
C27H32N2O4
Target:
Ligands for Target Protein for PROTAC,PD-1/PD-L1
Application Notes:
MCE Product type: Reference compound
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