Y-29794 is a selective, orally active inhibitor for non-peptide prolyl endopeptidase (PREP), with an IC50 of 3 nM and a Ki of 0.95 nM. Y-29794 enhances the effect of thyrotropin-releasing hormone (TRH) on the release of ACh in the rat hippocampus, exhibits potential neuroprotective efficacy. Y-29794 exhibits anticancer activity through inhibition of the IRS1-AKT-mTORC1 pathway. Y-29794 penetrates the brain-blood barrier (BBB)[1][2].
Molecular Weight:
418.66
CAS Number:
[129184-48-1]
Formula:
C23H34N2OS2
Target:
Prolyl Endopeptidase (PREP)
Application Notes:
Reference compound
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