ONO 1603, a novel prolyl endopeptidase inhibitor investigated as a potential antidementia drug, demonstrated neuroprotective and neurotrophic effects in cerebellar granule cells similar to tetrahydroaminoacridine (THA). At a concentration of 0.03 microM, ONO 1603 promoted neuronal survival, enhanced neurite outgrowth, increased m3-muscarinic acetylcholine receptor (mAChR) mRNA levels, and stimulated mAChR-mediated signaling pathways. These findings suggest that ONO 1603 shares pharmacological similarities with THA, indicating its potential as a therapeutic agent for Alzheimers disease by enhancing cholinergic neurotransmission and neuronal function[1].
Molecular Weight:
322.79
CAS Number:
[117427-00-6]
Formula:
C16H19ClN2O3
Target:
Prolyl Endopeptidase (PREP)
Application Notes:
MCE Product type: Reference compound
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