S-Methyl-N,N-diethylthiolcarbamate (DETC-Me, DDTC-Me) is the active metabolite of the aldehyde dehydrogenase inhibitor disulfiram (HY-B0240). It is produced by the methylation of the disulfiram metabolite diethyldithiocarbamate in mouse liver microsomes. S-Methyl-N,N-diethylthiolcarbamate (DETC-Me, DDTC-Me) inhibits rat liver low Km aldehyde dehydrogenase (ALDH) (ID50=15.5 mg/kg). When administered at a dose of 20.6 mg/kg, it decreases mean arterial pressure (MAP) and increases heart rate in rats during ethanol stimulation.
Molecular Weight:
163.30
Purity:
99.77
CAS Number:
[686-07-7]
Formula:
C6H13NS2
Target:
Aldehyde Dehydrogenase (ALDH)
Application Notes:
MCE Product type: Reference compound
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