JAK-IN-23 is an orally active double inhibitor of JAK/STAT and NF-kappaB. JAK-IN-23 can inhibit JAK1/2/3 with IC50 values of 8.9 nM, 15 nM and 46.2 nM, respectively. JAK-IN-23 has potent inhibitory activities against interferon-stimulated genes (ISG) and NF-kappaB pathways with IC50 values of 3.3 nM and 150.7 nM, respectively. JAK-IN-23 has great anti-inflammatory that decreases the release of various proinflammatory factors. JAK-IN-23 can be used for the research of inflammatory bowel disease (IBD)[1].
Molecular Weight:
441.35
Purity:
98.88
CAS Number:
[3031837-35-8]
Formula:
C23H22Cl2N4O
Target:
JAK,NF-kappaB,STAT,STING
Application Notes:
MCE Product type: Reference compound
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