PNRI-299 is a selective AP-1 transcription inhibitor with an IC50 of 20 uM. PNRI-299 is a selective APE/Ref-1 inhibitor. PNRI-299 has no effect on NF-kappaB transcription or thioredoxin (up to 200 uM). PNRI-299 significantly reduces airway eosinophil infiltration, mucus hypersecretion, edema, and IL-4 levels in a mouse asthma model[1][2][3].
Molecular Weight:
401.37
CAS Number:
[550368-41-7]
Formula:
C21H15N5O4
Target:
Interleukin Related
Application Notes:
MCE Product type: Reference compound
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