Vimentin-IN-1 is a FiVe1 derivative, an orally active and selective anticancer agent. FiVe1 binds type III intermediate filament protein vimentin (VIM), to induce hyperphosphorylation of Ser56, resulting selective disruption of mitosis and multinucleation in transformed VIM-expressing mesenchymal cancer cells. Vimentin-IN-1 shows better oral bioavailability and pharmacokinetic profiles than FiVe1[1].
Molecular Weight:
389.28
Purity:
99.74
CAS Number:
[2319587-80-7]
Formula:
C19H18Cl2N4O
Target:
Mitosis,Proteasome
Application Notes:
MCE Product type: Reference compound
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