PI3K/Akt/CREB activator 1 (compound AE-18) is a potent, orally active PI3K/Akt/CREB activator. PI3K/Akt/CREB activator 1 promotes neuronal proliferation, induced differentiation of Neuro-2a cells into a neuron-like morphology, and accelerated the establishment of axon-dendrite polarization of primary hippocampal neurons through upregulating brain-derived neurotrophic factor via the PI3K/Akt/CREB pathway. PI3K/Akt/CREB activator 1 can be used in research of vascular dementia (VaD)[1].
Molecular Weight:
381.32
Purity:
98.64
CAS Number:
[2708177-73-3]
Formula:
C19H15F4NO3
Target:
Akt,Epigenetic Reader Domain,PI3K
Application Notes:
MCE Product type: Reference compound
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