TAK-960 dihydrochloride is an orally available, selective inhibitor of polo-like kinase 1 (PLK1), with an IC50 of 0.8 nM. TAK-960 dihydrochloride also shows inhibitory activities against PLK2 and PLK3, with IC50s of 16.9 and 50.2 nM, respectively. TAK-960 dihydrochloride inhibits proliferation of multiple cancer cell lines and exhibits significant efficacy against multiple tumor xenografts[1].
Molecular Weight:
634.52
Purity:
99.19
Formula:
C27H36Cl2F3N7O3
Target:
Polo-like Kinase (PLK)
Application Notes:
MCE Product type: Reference compound
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