TAK-285 is a potent, selective, ATP-competitive and orally active HER2 and EGFR(HER1) inhibitor with IC50 of 17 nM and 23 nM, respectively. TAK-285 is >10-fold selectivity for HER1/2 than HER4, and less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc. TAK-285 has effective antitumor activity[1]. TAK-285 can cross the blood-brain barrier (BBB)[2].
Molecular Weight:
547.96
Purity:
98.99
CAS Number:
[871026-44-7]
Formula:
C26H25ClF3N5O3
Target:
EGFR
Application Notes:
MCE Product type: Reference compound
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