NADPH oxidase-IN-1 is an orally active NADPH oxidase (Nox) inhibitor, related with neuronal inflammation. NADPH oxidase-IN-1 can cross the blood-brain barrier (BBB), inhibits Nox2 and Nox4 with IC50s of 1.9 µM and 2.47 µM, respectively. NADPH oxidase-IN-1 suppresses pro-inflammatory cytokines production and LPS-mediated microglial migration, also has in vivo efficacy[1].
Molecular Weight:
373.51
Purity:
99.69
CAS Number:
[2762405-17-2]
Formula:
C20H27N3O2S
Target:
NADPH Oxidase
Application Notes:
MCE Product type: Reference compound
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