Meglitinide is an ATP-sensitive potassium (KATP) channel inhibitor. Meglitinide exhibits IC50 values of 0.26 µM, 0.53 µM and 1.6 µM against KATP channels containing SUR1, SUR2A and SUR2B, respectively, with a Kd value of 7 µM for both SUR1 and SUR2A, and a Kd value of 8 µM for SUR2B. Meglitinide binds to the SUR1, SUR2A and SUR2B subunits with high affinity to close KATP channels, acting on a binding site shared by all SUR subtypes, and its interaction with SUR1 carrying the S1237Y mutation remains unchanged. Meglitinide is applicable to research related to type 2 diabetes[1].
Molecular Weight:
333.77
CAS Number:
[54870-28-9]
Formula:
C17H16ClNO4
Target:
Potassium Channel
Application Notes:
MCE Product type: Reference compound1
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