CUR5g is a potent autophagy inhibitor. CUR5g selectively inhibits autophagosome degradation in cancer cells by blocking autophagosome-lysosome fusion. CUR5g blocks the recruitment of STX17 to autophagosomes via a UVRAG-dependent mechanism, resulting in the inability of autophagosomes to fuse with lysosomes. CUR5g improves the anticancer effect of Cisplatin (HY-17394) against A549 cells both in vitro and in vivo[1].
Molecular Weight:
344.41
Purity:
98.69
CAS Number:
[1370032-20-4]
Formula:
C22H20N2O2
Target:
Autophagy
Application Notes:
MCE Product type: Reference compound
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