LY1 is a potent, selective and covalent inhibitor against both SARS-CoV-2 PLpro and Mpro with Kd values of 1.5 µM and 2.3 µM for Mpro C145A protein and PLpro C111A protein, respectively. LY1 potent against the viral proteases, with IC50s of 0.12 µM and 0.99 µM against Mpro and PLpro. LY1 shows high selectivity over other kinases, human proteases and metalloenzyme[1].
Molecular Weight:
430.91
Purity:
98.01
CAS Number:
[2883813-32-7]
Formula:
C20H19ClN4O3S
Target:
SARS-CoV
Application Notes:
MCE Product type: Reference compound
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