HDAC6 degrader-3 is a potent and selective HDAC6 degrader via ternary complex formation and the ubiquitin-proteasome pathway with a DC50 value of 19.4 nM. HDAC6 degrader-3 has IC50s of 4.54 nM and 0.647 µM for HDAC6 and HDAC1, respectively. HDAC6 degrader-3 causes strong hyperacetylation of alpha-tubulin[1].
Molecular Weight:
883.80
Purity:
98.12
CAS Number:
[2785404-83-1]
Formula:
C41H41F4N7O11
Target:
HDAC,PROTACs
Application Notes:
MCE Product type: Reference compound
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